<p>Synergistic Anti-Staphylococcal Activity Of Niosomal Recombinant Lysostaphin-LL-37</p>

Lysostaphin: an enzymatic approach to staphylococcal disease. 3. Combined lysostaphin-methicillin therapy of established staphylococcal abscesses in mice.

Serious staphylococcal infections continue to pose therapeutic problems despite the availability of antimicrobial agents that are effective against staphylococci in vitro. Much suggests that this relates, in part, to the nature of the basic lesion in staphylococcal disease. The abscess is the hallmark of staphylococcal disease, and many therapeutic failures appear to result from the inability o...

Lysostaphin: A Staphylococcal Bacteriolysin with Potential Clinical Applications

Lysostaphin is an antimicrobial agent belonging to a major class of antimicrobial peptides and proteins known as the bacteriocins. Bacteriocins are bacterial antimicrobial peptides which generally exhibit bactericidal activity against other bacteria. Bacteriocin production is a self-protection mechanism that helps the microorganisms to survive in their natural habitats. Bacteriocins are current...

Lysostaphin as a potential therapeutic agent for staphylococcal biofilm eradication.

The aim was to study the activity of lysostaphin in monotherapy or in combination with oxacillin, towards biofilms built by clinical and reference S. aureus and S. epidermidis strains in the wells of microplate, in the chambers of a LabTekII chamber slide or on the polyethylene catheter. MICs of oxacillin and lysostaphin for planktonic bacteria were determined according to the standards of NCCL...

Lytic activity of the recombinant staphylococcal bacteriophage Φ

In-vitro bactericidal activity of recombinant lysostaphin on biofilm producing methicillin resistant Staphylococcus aureus

Department of Microbiology, Melaka Manipal Medical College (Manipal Campus) Manipal University, Manipal, Karnataka 576104, India Department of Pharmaceutical Biotechnology, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 576104, India Department of Pharmaceutical Chemistry, Manipal College of Pharmaceutical Sciences, Manipal University, Manipal, Karnataka 5761...